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PQQ Rich Foods

Several readers have inquired about PQQ in food and whether diet alone is sufficient to obtain enough pyrroloquinoline quinone to be biologically effective. The answer — relative to what is known about optimizing growth in rodent nutritional growth experimental models — is probably yes. However, some rather broad assumptions have to be made, because of the limited amount of data regarding the forms of PQQ in different foods.

Pyrroloquinoline quinone rich foods
Natto and green tea are high in PQQ

For perspective, Dr. Steinberg out of the University of California, Davis has presented data that suggests PQQ is needed at ~200-400 micrograms per kilogram of dry food. Given that most lactating mammals have the same vitamin and mineral requirements, when those amounts are expressed on a food energy or dry food weight basis, one might infer humans — who consume about 300 to 500 grams of dry food per day (about 2000 Kcal) — need up to 100-200 micrograms of PQQ per day.

In the section, Pyrroloquinoline quinone and CoQ10, we previously discussed that pyrroloquinoline quinone exists as salts or as complex derivatives of amino acids, imidazolopyrroloquinolines, and abbreviated IPQs. For PQQ consumed in the diet (even as a supplement), much of it is converted to IPQ (Pyrroloquinoline Quinone Improves Growth and Reproductive Performance in Mice Fed Chemically Defined Diets). In human milk, the ratio of IPQ to PQQ was estimated to be about 8:1 (Characterization of Pyrroloquinoline Quinone Amino Acid Derivatives by Electrospray Ionization Mass Spectrometry and Detection in Human Milk). In foods, it is reported that the ratio under assay conditions may be closer to 2:1 (Simple and Sensitive Method for Pyrroloquinoline Quinone (PQQ) Analysis in Various Foods Using Liquid Chromatography/Electrospray-Ionization Tandem Mass Spectrometry). Regrettably, tissue preparation, acidity or alkalinity, and temperature can impact and alter PQQ and IPQ values. For example, under alkaline conditions (above pH8) almost all pyrroloquinoline quinone is converted to derivatives when PQQ is introduced into a complex mixture or environment.

PQQ in Food *

PQQ in Food

* In addition to the values taken from published papers, some of the values are from conference reports or abstracts presented at meetings. As noted in the main body copy, there is a lot of variability. Kamazama et al. in their 1995 Biochemistry Journal paper report ~0.06 micrograms as the PQQ concentration in dried skim milk per 100 grams of milk solids. However, later in an abstract of a paper presented at the Biochemical Society Transactions in 2000 in England, they report detection and quantization of IPQ in human breast milk at 0.14 to 5.5 microgram/100 mL of fresh milk or 1.4 to 55 micrograms per 100 grams of milk solids. Given the variability, my estimates are inline with the data reported in Characterization of Pyrroloquinoline Quinone Amino Acid Derivatives by Electrospray Ionization Mass Spectrometry and Detection in Human Milk, i.e. ~140-180 micrograms (PQQ +IPQ) per 100 g of milk solids. Moreover, Fluckinger et al. reported that the PQQ concentration of milk is 15-150 micrograms/100 mL or 150 to 500 micrograms/100 grams of bovine milk solids. For the Fluckinger assays PQQ was separated and then measured using a 16-channel electrochemical detector, a highly precise and sensitive procedure. All other assay involved sophisticated separation and mass spectrometer for detection, also highly precise and sensitive. The information above is also derived from the work of Kumazawa et al. (Levels of pyrroloquinoline quinone in various foods). Some of the values are higher than corresponding values for foods analyzed by Noji et al. (Simple and Sensitive Method for Pyrroloquinoline Quinone (PQQ) Analysis in Various Foods Using Liquid Chromatography/Electrospray-Ionization Tandem Mass Spectrometry). Although the number of foods analyzed is small, an important finding is that PQQ has been observed in all tissues analyzed to date in both plants and animals.

In the above table, Column A indicates some of the currently available sources for pyrroloquinoline quinone (for which compositional values have been obtained). Column B are amounts taken mostly from the Kumazawa et al. paper, but are expressed as micrograms of PQQ per 100 grams of food (~1/4 lb) and not as nanograms per grams of food (as they were originally reported). Next, in column C, the amounts in column B are multiplied by 5-10 to obtain an estimate of micrograms of PQQ per 100 grams of dried foods or so-called food solids (e.g., given that most of the food items mentioned contain at least 75% water or more). Column D requires making some guesses. As noted, some researchers have reported that IPQ is 5 to 8 times greater than the amount of PQQ in tissues. While others have reported a low ratio of 2 to 3 for IPQ to PQQ. Thus, the apparent IPQ + PQQ values given in Column D range from the lowest to highest amounts obtained by multiplying arbitrarily the values in Column C by 2 or 8. Column E is even trickier. It represents the estimated amounts consumed per day for an “ideal” person consuming a maintenance diet of 2000 calories per day. Regarding the diet consumed, the values for the major food categories are based on the estimated amounts consumed per day (on a dry weight basis) derived from values given in the USDA publication, Profiling Food Consumption in America. The question is whether a typical selection of food can yield the minimum amount that corresponds to optimizing growth in animal models, i.e. about 100-200 microgram per day.

If you’re curious about pyrroloquinoline quinone intake please visit PQQ Dosage, What size pyrroloquinoline quinone pills should I take?.

Regarding various conclusions, the first is that much better data is needed. However, setting aside that concern and assuming the actual values for PQQ in foods may be at the median (middle) of the estimates provided, one can guess that a typical intake in humans is indeed about 0.3 mg or 300 micrograms of pyrroloquinoline quinone per day or more. That amount is very much is line with the amount of pyrroloquinoline quinone or PQQ + IPQ needed to stimulate growth in animals. It is also an amount that is found in human milk, which is always a good starting point in assessing a need related to growth or maintenance.

So what can we conclude? In the paper by Kumazawa et al. Levels of pyrroloquinoline quinone in various foods it is stated that probably the PQQ in animal tissues are derived at least in part from their diet and that the levels of pyrroloquinoline quinone in plant tissues are in the aggregate about 10 times those in animal tissues. In a review by Rucker et al. Potential physiological importance of pyrroloquinoline quinone, the same conclusion was reached, particularly given that stomach microflora does not make an abundance of PQQ . The data also beg the question do we need supplements and if so how much? Many of the PQQ products sold are in the 10-20 mg range. As indicated in the section — PQQ Dosage, What size pyrroloquinoline quinone pills should I take? — we discuss that the reasonable pyrroloquinoline quinone dosage, like many supplements, for an active adult is probably the result of an arbitrary decision.

As a final point, unlike many dietary factors and biofactors, PQQ and its derivatives are sustained in tissues and seem to play a fundamental role related to energy metabolism. In this regard, the need for PQQ might vary depending on your desired outcome.

Comments

tayo
Reply

I am 57 year old how suffering from knee trouble and low energy, how much PQQ supplement can i take a day?

Michael Rucker
Reply

Hi Tayo, it is safe to take 20 milligrams of pyrroloquinoline quinone (methoxatin) a day. Try that and see how it makes you feel. If you aren’t happy with the results, increasing the dosage isn’t likely to produce different results.

[...] of PQQ are needed to elicit given responses.  That PQQ is present in a wide variety of foods (see PQQ Rich Foods) is due in large part to its function and presence in plants and fermented (bacterially derived [...]

Friedrich
Reply

Calculating the amount of “PQQ-rich-food” to reach the therapeutically used 10 mg PQQ means multiplying the concentrations. No one can eat such amounts of banana, kiwi, green tea, etc. reaching therapeutic levels of natural PQQ. Maybe in a whole year, but not in a day.

[...] quinone is better classified as one of a few compounds that act as cell signaling molecules. Pyrroloquinoline quinone is prevalent in many foods associated with a healthy diet, so people that eat well-rounded meals should get enough to sustain their biological need. It is a [...]

[...] PQQ is a bacterial biofactor present in soil, on plants, and in animals. It stimulates plant and bacterial growth, and when animals eat the plants (or soil) that contains the bacteria, they also get the PQQ. Biofactors extremely similar to PQQ have even been detected in interstellar dust, suggesting that it has been an important component of the global ecosystem for billions of years. As is the wont of other bioactive compounds with similarly expansive legacies and ubiquitousness (sunlight/vitamin D comes to mind, as do essential minerals), PQQ appears to interact with a number of physiological processes, including both mitochondrial function and biogenesis. It improves mitochondrial respiratory control and stimulates mitochondrial biogenesis. One could probably write an entire article on this stuff’s interactions with the mitochondria, and I won’t, but I will direct interested parties to a comprehensive paper on the subject (PDF). Most folks focus on supplementing with PQQ, which can be a bit expensive, but another option is to eat natto (fermented soybeans, a legume, but a highly nutritious form that contains vitamin K2 in addition to PQQ) and drink green tea, both of which are high in PQQ. [...]

Reggie Govender
Reply

Hi I live in Johannesburg, South Africa and I require the vitamin supplement PQQ to administer to my wife who has had bilateral strokes and is in a semi coma state for the last 6 months. I have done some research on this compound and I would do or try anything substantial to help my wife to recover from her illness. We have been married for the last 20 years and have two wonderful children and I would not miss out on any opportunity to help my wife to get better. Please assist in trying to get the product to me in South Africa.

Thanks and Regards,

Reggie Govender

Michael Rucker
Reply

Reggie, I’m sorry to hear about your situation. It is my unprofessional opinion that pyrroloquinoline quinone would not be an appropriate product for the ailments facing your wife. That said, it is important that you follow the recommendations of your chosen medical professionals. I wish the best for you and your family.

Chris
Reply

I want to know all the foods that contain quinone please because my doctor asked me not to eat any food containing quinone. Right now I’m confused about the foods that contain it. Mike, can you help me?

Celia Rausch
Reply

Would pyrroloquinoline quinone be beneficial for someone with Parkinson’s disease?

Michael Rucker
Reply

Hi Celia, as you are probably aware there is very good evidence that PQQ can have a positive influence on mitochondrial function and neural/muscular interactions based on animals and some related human studies. While there is little work directly linked to PQQ, I often go to the research literature addressing resveratrol, which has some of the same biological effects as PQQ. Knowledge regarding resveratrol has been around about 15-20 years longer than PQQ – particularly as it relates to putative health attributes. For example, there are about 70-80 papers that are relevant to resveratrol and Parkinson’s. You may find the review article dealing with resveratrol and Parkinson’s. A problem with making a definitive guess about either (resveratrol or PQQ) is that neuronal cells turn over (are regenerated) very slowly by multiple and complex mechanisms. Moreover, studies in humans are limited and the relevant animal studies are most often done in very young animals instead older adults. The effects of these compounds are much more dynamic in young vs. older animal models. Also, it is usually difficult to make the case that a single compound, particularly a given dietary antioxidant, is going to have a specific or immediately noticeable impact on a specific disease.

Some perspectives regarding PQQ – PQQ has been on the market for 5-6 years with no known negative side effects (to my knowledge). PQQ is also about 25-50 times more potent than resveratrol. In human term, 5-20 mg of PQQ day elicits about the same responses as 100-500 mg of resveratrol. PQQ is also found universally in the diet.

For more on the topic please see the post: PQQ and Parkinson’s disease

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